- Single-center study on clinicopathological and typical molecular pathologic features of metastatic brain tumor
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Su Hwa Kim, Young Suk Lee, Sung Hak Lee, Yeoun Eun Sung, Ahwon Lee, Jun Kang, Jae-Sung Park, Sin Soo Jeun, Youn Soo Lee
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J Pathol Transl Med. 2023;57(4):217-231. Published online July 11, 2023
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DOI: https://doi.org/10.4132/jptm.2023.06.10
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Abstract
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- Background
The metastatic brain tumor is the most common brain tumor. The aim of this study was to demonstrate the clinicopathological and molecular pathologic features of brain metastases (BM).
Methods A total of 269 patients were diagnosed with BM through surgical resection at Seoul St. Mary’s Hospital from January 2010 to March 2020. We reviewed the clinicopathological features and molecular status of primary and metastatic brain tissues using immunohistochemistry and molecular pathology results.
Results Among 269 patients, 139 males and 130 females were included. The median age of primary tumor was 58 years (range, 13 to 87 years) and 86 patients (32.0%) had BM at initial presentation. Median BM free interval was 28.0 months (range, 1 to 286 months). The most frequent primary site was lung 46.5% (125/269), and followed by breast 15.6% (42/269), colorectum 10.0% (27/269). Epidermal growth factor receptor (EGFR) mutation was found in 50.8% (32/63) and 58.0% (40/69) of lung primary and BM, respectively. In both breast primary and breast cancer with BM, luminal B was the most frequent subtype at 37.9% (11/29) and 42.9% (18/42), respectively, followed by human epidermal growth factor receptor 2 with 31.0% (9/29) and 33.3% (14/42). Triple-negative was 20.7% (6/29) and 16.7% (7/42), and luminal A was 10.3% (3/29) and 7.1% (3/42) of breast primary and BM, respectively. In colorectal primary and colorectal cancer with BM, KRAS mutation was found in 76.9% (10/13) and 66.7% (2/3), respectively.
Conclusions We report the clinicopathological and molecular pathologic features of BM that can provide useful information for understanding the pathogenesis of metastasis and for clinical trials based on the tumor’s molecular pathology.
- Molecular characteristics of meningiomas
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Young Suk Lee, Youn Soo Lee
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J Pathol Transl Med. 2020;54(1):45-63. Published online January 15, 2020
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DOI: https://doi.org/10.4132/jptm.2019.11.05
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Abstract
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- Meningioma is the most common primary intracranial tumor in adults. The grading of meningioma is based on World Health Organization criteria, which rely on histopathological features alone. This grading system is unable to conclusively predict the clinical behavior of these tumors (i.e., recurrence or prognosis in benign or atypical grades). Advances in molecular techniques over the last decade that include genomic and epigenomic data associated with meningiomas have been used to identify genetic biomarkers that can predict tumor behavior. This review summarizes the molecular characteristics of meningioma using genetic and epigenetic biomarkers. Molecular alterations that can predict meningioma behavior may be integrated into the upcoming World Health Organization grading system.
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Citations
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- The Natural History and Treatment of Meningiomas: An Update
Arsene Daniel Nyalundja, Fabrice Mugisha, Claire Karekezi Seminars in Neurology.2024; 44(01): 001. CrossRef - Epidemiology, Genetics, and DNA Methylation Grouping of Hyperostotic Meningiomas
Gray Umbach, Edwina B. Tran, Charlotte D. Eaton, Abrar Choudhury, Ramin Morshed, Javier E. Villanueva-Meyer, Philip V. Theodosopoulos, Stephen T. Magill, Michael W. McDermott, David R. Raleigh, Ezequiel Goldschmidt Operative Neurosurgery.2024;[Epub] CrossRef - Recurrence of Resected Skull Base Meningiomas during Long-term Follow-up: Incidence and Predisposing Factors
Joshua Ian Macarthur, Cathal John Hannan, Callum Howard, Jane Halliday, Omar Nathan Pathmanaban, Charlotte Hammerbeck-Ward, Scott A. Rutherford, Andrew T. King Journal of Neurological Surgery Part B: Skull Base.2024;[Epub] CrossRef - The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care
S. Joy Trybula, Mark W. Youngblood, Constantine L. Karras, Nikhil K. Murthy, Amy B. Heimberger, Rimas V. Lukas, Sean Sachdev, John A. Kalapurakal, James P. Chandler, Daniel J. Brat, Craig M. Horbinski, Stephen T. Magill Cancers.2024; 16(9): 1753. CrossRef - DNA methylation profiling of meningiomas highlights clinically distinct molecular subgroups
Jyotsna Singh, Ravi Sharma, Nidhi Shukla, Priya Narwal, Amit Katiyar, Swati Mahajan, Saumya Sahu, Ajay Garg, Mehar C. Sharma, Ashish Suri, Chitra sarkar, Vaishali Suri Journal of Neuro-Oncology.2023; 161(2): 339. CrossRef - Spinal meningiomas, from biology to management - A literature review
Nicolas Serratrice, Imène Lameche, Christian Attieh, Moussa A Chalah, Joe Faddoul, Bilal Tarabay, Rabih Bou-Nassif, Youssef Ali, Joseph G Mattar, François Nataf, Samar S Ayache, Georges N Abi Lahoud Frontiers in Oncology.2023;[Epub] CrossRef - Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression
Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis, Katharine J Drummond BMC Cancer.2023;[Epub] CrossRef - Actualización sobre el meningioma: correlación clínico-radiológica y radio-patológica
A. Navarro-Ballester, M. Aleixandre-Barrachina, S.F. Marco-Doménech Radiología.2023; 65(5): 458. CrossRef - SMARCE1-related meningiomas: A clear example of cancer predisposing syndrome
Erika Fiorentini, Laura Giunti, Andrea Di Rita, Simone Peraio, Carla Fonte, Chiara Caporalini, Anna Maria Buccoliero, Maria Luigia Censullo, Giulia Gori, Alice Noris, Rosa Pasquariello, Roberta Battini, Rossana Pavone, Flavio Giordano, Sabrina Giglio, Ber European Journal of Medical Genetics.2023; 66(7): 104784. CrossRef - Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas
Liguo Ye, Shi’ao Tong, Yaning Wang, Yu Wang, Wenbin Ma Journal of Cancer Research and Clinical Oncology.2023; 149(12): 9857. CrossRef - Integrated clinical genomic analysis reveals xenobiotic metabolic genes are downregulated in meningiomas of current smokers
A. Basit Khan, Rajan Patel, Malcolm F. McDonald, Eric Goethe, Collin English, Ron Gadot, Arya Shetty, Shervin Hosseingholi Nouri, Arif O. Harmanci, Akdes S. Harmanci, Tiemo J. Klisch, Akash J. Patel Journal of Neuro-Oncology.2023; 163(2): 397. CrossRef - DNA methylation meningioma biomarkers: attributes and limitations
Zhaohui Li, Yufei Gao, Jinnan Zhang, Liang Han, Hang Zhao Frontiers in Molecular Neuroscience.2023;[Epub] CrossRef - Meningioma: A Biography—Tumor Forever Tied to the Origins and “Soul of Neurosurgery”
Nolan J. Brown, Zach Pennington, Cathleen C. Kuo, Julian Gendreau, Sachiv Chakravarti, Rohin Singh, Dontré M. Douse, Jamie J. Van Gompel World Neurosurgery.2023; 178: 191. CrossRef - Molecular genetic features of meningiomas
E.S. Makashova, N.V. Lasunin, M.V. Galkin, S.V. Zolotova, K.O. Karandasheva, A.V. Golanov Voprosy neirokhirurgii imeni N.N. Burdenko.2023; 87(4): 101. CrossRef - Novel Advances in Treatment of Meningiomas: Prognostic and Therapeutic Implications
Gerardo Caruso, Rosamaria Ferrarotto, Antonello Curcio, Luisa Metro, Francesco Pasqualetti, Paola Gaviani, Valeria Barresi, Filippo Flavio Angileri, Maria Caffo Cancers.2023; 15(18): 4521. CrossRef - Update on meningioma: Clinical-radiological and radio-pathological correlation
A. Navarro-Ballester, M. Aleixandre-Barrachina, S.F. Marco-Doménech Radiología (English Edition).2023; 65(5): 458. CrossRef - Early Preventive Strategies and CNS Meningioma – Is This Feasible? A Comprehensive Review of the Literature
Daniel Sescu, Aminta Chansiriwongs, Katarzyna Julia Minta, Jyothi Vasudevan, Chandrasekaran Kaliaperumal World Neurosurgery.2023; 180: 123. CrossRef - Domestic Animal Models of Central Nervous System Tumors: Focus on Meningiomas
Michele Tomanelli, Tullio Florio, Gabriela Vargas, Aldo Pagano, Paola Modesto Life.2023; 13(12): 2284. CrossRef - The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications
Stephanie M. Robert, Shaurey Vetsa, Arushii Nadar, Sagar Vasandani, Mark W. Youngblood, Evan Gorelick, Lan Jin, Neelan Marianayagam, E Zeynep Erson-Omay, Murat Günel, Jennifer Moliterno Journal of Neuro-Oncology.2022; 156(2): 205. CrossRef - Clinical presentation, diagnostic findings and outcome of dogs undergoing surgical resection for intracranial meningioma: 101 dogs
Alexander K. Forward, Holger Andreas Volk, Giunio Bruto Cherubini, Tom Harcourt-Brown, Ioannis N. Plessas, Laurent Garosi, Steven De Decker BMC Veterinary Research.2022;[Epub] CrossRef - Sphenoid wing meningiomas: peritumoral brain edema as a prognostic factor in surgical outcome
Abdalrahman Nassar, Volodymyr Smolanka, Andriy Smolanka, Dipak Chaulagain, Oleg Devinyak Neurosurgical Review.2022; 45(4): 2951. CrossRef - Potential Molecular Mechanisms of Recurrent and Progressive Meningiomas: A Review of the Latest Literature
Wenjie Peng, Pei Wu, Minghao Yuan, Bo Yuan, Lian Zhu, Jiesong Zhou, Qian Li Frontiers in Oncology.2022;[Epub] CrossRef - Case Report: Upper Thoracic Purely Extradural Spinal Meningioma With Nerve Root Attachment: A Case Report and Literature Review
Zhao-Lin Wang, Jian-Hui Mou, Dong Sun, Peng Liu Frontiers in Surgery.2022;[Epub] CrossRef - Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)
Jiaojiao Deng, Lingyang Hua, Liuguan Bian, Hong Chen, Ligang Chen, Hongwei Cheng, Changwu Dou, Dangmurenjiapu Geng, Tao Hong, Hongming Ji, Yugang Jiang, Qing Lan, Gang Li, Zhixiong Liu, Songtao Qi, Yan Qu, Songsheng Shi, Xiaochuan Sun, Haijun Wang, Yongpi Chinese Medical Journal.2022; 135(16): 1894. CrossRef - Оновлена інформація про менінгіоми крила клиноподібної кістки
Abdalrahman Nassar, Volodymyr Smolanka INTERNATIONAL NEUROLOGICAL JOURNAL.2022; 18(1): 43. CrossRef - The Prognostic Value of Methylation Signatures and NF2 Mutations in Atypical Meningiomas
Rahmina Meta, Henning B. Boldt, Bjarne W. Kristensen, Felix Sahm, Wenche Sjursen, Sverre H. Torp Cancers.2021; 13(6): 1262. CrossRef - Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis
Suha Bachir, Sanjit Shah, Scott Shapiro, Abigail Koehler, Abdelkader Mahammedi, Ravi N. Samy, Mario Zuccarello, Elizabeth Schorry, Soma Sengupta International Journal of Molecular Sciences.2021; 22(2): 690. CrossRef - Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions
Christian Ogasawara, Brandon D. Philbrick, D. Cory Adamson Biomedicines.2021; 9(3): 319. CrossRef - The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma
Minsun Jung, Seong-Ik Kim, Ka Young Lim, Jeongmo Bae, Chul-Kee Park, Seung Hong Choi, Sung-Hye Park, Jae-Kyung Won Human Pathology.2021; 115: 96. CrossRef - Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma
Gerardo Cazzato, Valeria Internò, Antonietta Cimmino, Raffaella Messina, Marco Tucci, Teresa Lettini, Leonardo Resta, Giuseppe Ingravallo Diseases.2021; 9(3): 63. CrossRef - An Overview of Managements in Meningiomas
Lianhua Zhao, Wei Zhao, Yanwei Hou, Cuixia Wen, Jing Wang, Pei Wu, Zaiyu Guo Frontiers in Oncology.2020;[Epub] CrossRef - Multi-Omics Analysis in Initiation and Progression of Meningiomas: From Pathogenesis to Diagnosis
Jiachen Liu, Congcong Xia, Gaiqing Wang Frontiers in Oncology.2020;[Epub] CrossRef - Molecular Mechanism and Approach in Progression of Meningioma
Zhiwei Shao, Lihong Liu, Yanghao Zheng, Sheng Tu, Yuanbo Pan, Sheng Yan, Qichun Wei, Anwen Shao, Jianmin Zhang Frontiers in Oncology.2020;[Epub] CrossRef - Multiple meningiomas: does quantity matter? a population-based survival analysis with underlined age and sex differences
Andres Ramos-Fresnedo, Ricardo A. Domingo, Tito Vivas-Buitrago, Larry Lundy, Daniel M. Trifiletti, Mark E. Jentoft, Amit B. Desai, Alfredo Quiñones-Hinojosa Journal of Neuro-Oncology.2020; 149(3): 413. CrossRef - Meningioma: A Review of Clinicopathological and Molecular Aspects
Kristin Huntoon, Angus Martin Shaw Toland, Sonika Dahiya Frontiers in Oncology.2020;[Epub] CrossRef - Neues zur Einteilung und Therapie von Meningeomen
Corinna Seliger, Wolfgang Wick Neurologie up2date.2020; 3(04): 343. CrossRef
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